摘要
目的以健康老年人群呼吸道菌群为研究基础，在此基础上研究老年呼吸道感染过程中随着疾病的发展呼吸道菌群的变化趋势及感染治疗过程中呼吸道菌群的变化趋势。方法采集2003年7月-2005年12月间老年人（年龄大于60岁）健康组60例在不同季节的咽拭子进行需氧培养、厌氧培养、二氧化碳培养；同时采集60例门诊呼吸道感染的老年患者（未使用抗生素治疗）咽拭子及120例呼吸道反复感染老年患者（使用5d广谱抗生素后）的咽拭子进行同样的培养。通过数据分析在不同季节老年人群组的咽部正常菌群的分布及感染状态下呼吸道菌群数量变化和失调。结果健康老年人群之间咽拭子的细菌菌群分布和数量是无明显差异的（P〉0．05）；而老年感染组的咽拭子细菌菌群分布和数量与老年健康组有明显差异（P〈0．05）；对于120例老年呼吸道反复感染患者（在使用5d广谱抗生素后）其咽拭子细菌菌群分布和数量与老年健康组有明显差异（P〈0．05）；广谱抗生素应用后主要的致病菌为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、金黄色葡萄球菌、鲍曼不动杆菌和白假丝酵母菌等。结论呼吸道菌群在健康老年人群之间保持着一定的菌群数量稳定，但在呼吸道感染时其菌群可失调导致呼吸道感染。而且随着广谱抗生素的应用会选择出呼吸道高耐药的条件致病菌，尤其是铜绿假单胞菌和鲍曼不动杆菌。
Objective To study changes and tendency of normal flora at old people respiratory tract among health humanity and the process of infection,in order to improve how to protect useful normal flora. Methods Made aerobic cultivation, anaerobic culture,carbon dioxide cultivation on 240 samples of throat swab including different ages from 2003.7 to 2005. 12,at the same time,Analyzed the distribution＇of normal flora among old people of health humanity and the dysbiosis at respiratory tract at the condition of infection. Results The species and quantity of normal flora among old people was same （P〉0. 05）, It is imbalance,especially for old people after treating extended β-actamase Antibiotics. It could induce dysbacteriosis, the main infection bacterium was S. aure , E. coli , K. pneumoniae , P. aeruginosa ,S. maltophilia and C. albicans. Conclusion There are colonization density and abundance normal flora at respiratory tract. It keep stability and integrity eubiosis in host ,but the balance condition of host have been demaged ,easily often lead to respiratory infection,especially opportunistic pathogen to senile patients. Most of them is endogenous opportunistic infection,and could choice high resistant opportunistic pathogen especial P. aeruginosa and A. baumannii.
出处
《现代检验医学杂志》
CAS
2008年第4期72-74,共3页
Journal of Modern Laboratory Medicine
基金
陕西省西安市科技立项课题(项目编号SF200340)
关键词
老年呼吸道感染
菌群失调
old people respiratory tract infection
flora imbalance
