摘要
以工业废氢溴酸（48％）为原料，在浓硫酸存在下与正己醇反应，制取1-溴己烷。考察了反应条件对产率的影响，比较合适的反应条件为：n（正己醇）：n（氢溴酸）：n（浓硫酸）=1：1．15：1．38，反应时间3h，反应温度110—115℃。产率达96．3％。放大及重复实验同样得到了较高的、稳定的产率，说明该方案具有很好的再现性，粗产品经气相色谱分析证明无副产物。
1-Bromohexane was synthesized from waste industrial hydrobromic acid （48%） and n-hexanol using concentrated sulfuric acid as the catalyst. Various factors affecting the reaction were investigated. The optimal condition was as follow：the molar ratio of n-hexanol： hydrobromic acid：concentrated sulfuric acid was 1 ： 1.15 ： 1.38, the reaction mixture was refluxed for 3 h, the reaction temperature was 110 - 115 ℃ ,and the yield of isolated 1-bromohexane was up to 96.3%. A steady yield could be achieved through the scale-up and repeated experiments, indicating to the repeatability of this method. The crude product was analyzed by GC,and no by-product was detected.
出处
《化学试剂》
CAS
CSCD
北大核心
2008年第8期607-608,共2页
Chemical Reagents
关键词
1-溴己烷
浓硫酸
氢溴酸
1-bromohexane
concentrated sulfuric acid
hydrobromic acid
