摘要
目的观察大剂量甲基强的松龙冲击治疗视神经脊髓炎（neuromyelitisoptica，NMO）急性发作的临床疗效。方法对18例临床确诊为NMO急性发作的患者给予甲基强的松龙1000mg静脉滴注，每日1次，连续5d，然后改用泼尼松片剂口服，缓慢减量至停药，总疗程4～6周。采用近视力表对治疗前后视力进行比较，采用Barthel指数对入院第2天和治疗后14d患者的日常生活能力进行评价。结果所有患者经治疗后，15例日常生活能力改善，3例无效；所有病例治疗后视力显著改善，入院第2天与治疗后14dBarthel指数总评分相比有显著差异。结论大剂量甲基强的松龙冲击疗法对NMO急性发作治疗有效。[眼科新进展2008；28（8）：618-619]
Objective To observe curative effect of pulse therapy with high-dose intravenous mythlprednisone （MP） on acute neuromyelitis optica （ NMO ）. Methods Eighteen cases with NMO were treated with intravenous MP （ 1 g · d-1 ） for 5 days,followed by an oral prednisone taper （60 mg· d-1 ）, with gradual reduction over the ensuing 4 weeks to 6 weeks. After therapy,the visual acuity was compared by eye chart. The Barthel index was used to assess the activities of daily living on 2nd day and 14th day. Results The visual acuity was improved significantly in all cases. The effectiveness was significat in 15 cases（83.3% ）. The difference of Barthel index was statistically signif- icant （ P 〈 0. 05 ）. Conclusion Pulse therapy with high-dose intravenous mythlprednisone is effective on acute NMO. [Rec Aflv Ophthalmol 2008;28（8） ;618-619]
出处
《眼科新进展》
CAS
2008年第8期618-619,共2页
Recent Advances in Ophthalmology
关键词
视神经脊髓炎
甲基强的松龙
视力
neuromyelitis optica
mythlprednisone
visual acuity
