摘要
目的:利用血氧水平依赖性磁共振功能成像(BOLD-fMRI)技术研究急性期脑梗死患者短期康复治疗前后的手运动中枢激活体积、强度的变化特征,从而探讨脑梗死患者急性期手运动功能康复的机制。方法:选择首次、单发脑梗死急性期患者16例,其中康复治疗组8例和常规治疗组8例,分别于治疗前及治疗第14天进行fMRI检查,并采用Fugl-Meyer运动功能评分(FM评分)进行患手运动功能评定,记录治疗前后常规治疗组和康复治疗组中枢激活的体积、强度;同时选择10名健康志愿者进行单次fMRI检查,确定相同运动任务刺激后脑功能区位置和兴奋体积、强度等方面的变化规律。结果:16例脑梗死患者治疗后对侧SMC(sensorimotor cortex,SMC)激活体积、强度及FM评分大于治疗前(P<0.05),康复治疗组治疗前后患手运动激活对侧SMC体积、强度、FM评分较常规治疗组明显改变(P<0.05)。结论:脑梗死急性期进行早期康复治疗可以引起患侧SMC区相应的变化,加速患肢功能的恢复。
Objective：To observe the change of the active volume of motor cortex with bold oxygenation level dependent functional magnetic resonance imaging（BOLD-fMRI） in pre and post short time rehabilitation therapy of the acute stroke and analyze the characteristics in motor functional rehabilitation.Methods：16 patients（8 patients under general therapy only,8 patients under general and recuperatory therapy） were performed fMRI before and after therapy for 14 days,accompanied the FM scores.The motor cortex active volume was registed in the two groups under general therapy and recuperatory therapy.In order to provide the bases for patients,10 healthy volunteers were performed single fMRI to confirm the location and the volume of the active area by the same exercises.Results：16 patients＇ motor cortex active volume on fMRI and FM scores showed increment from pre to post therapy with significant differences.Under the sick hand exercises,the increase of the rehabilitation therapy groups is sharply more than that of the general therapy ones.Conclusion：Short time recuperatory therapy for the acute stroke could promote the patient＇s functional rehabilitation and the infarcted side SMC transforms with distinct effect.
出处
《脑与神经疾病杂志》
2008年第4期394-397,共4页
Journal of Brain and Nervous Diseases
关键词
功能磁共振成像
定量
脑梗死
手运动
康复
BOLD-fMRI Quantification Cerebral infarction Hand motor Rehabilitation
