摘要
目的:研究预后不良的早期霍奇金淋巴瘤(HL)的最佳治疗策略。方法:分析51例预后不良的早期HL单纯放疗(RT)或综合治疗(CMT)后的总生存期(OS)和无病生存期(DFS)。结果:RT组和CMT组的完全缓解率(CR)分别为75.0%和77.1%,χ2=0.028,P=0.867;RT组和CMT组的5和10年OS分别为85.7%、72.5%和93.6%、93.6%,P=0.510;5和10年DFS分别为81.2%、65.7%和100.0%、100.0%,P=0.06;RT组和CMT组的复发率分别为43.8%和22.9%,P=0.003。结论:CMT可以提高10年DFS率,降低复发率,但未明显延长OS。
OBJECTIVE： To study the optimal treatment strategy for the patients with unfavorable early stage Hodgkin lymphoma （HL）. METHODS： A retrospective study was performed. Fifty-one patients who were treated with radiation alone （RT） or combined modality therapy （CMT） were entered into the study. The endopoints included the response, the overall survival （OS）, the disease-free survival （DFS）, and the pattern of relapse. RESULTS： the complete responsive （CR） rates in the RT and CMT groups were 75.0% and 77. 1%（Х^2=0. 028, P： 0. 867）respectively. In the RT and CMT groups, the 5-year and 10-year OS were 85. 7%, 72. 5%and 93.6%, 93.6% （P= 0. 510）, respectively; and the 5-year, 10-year DFS rate were 81.2%, 65.7% and 100.0%, 100.0%（P=0.06）, respectively. The relapse rates in the RT group and CMT group were 43.8% and 22.9%, respectively （P=0. 003）. CONCLUSIONS： Compared with radiotherapy alone, CMT can improve 10- year DFS rate and decrease the relapse rate. However, the overall survival rate does not improve significantly.
出处
《中华肿瘤防治杂志》
CAS
2008年第14期1094-1096,共3页
Chinese Journal of Cancer Prevention and Treatment
