摘要
目的观察清开灵注射液静脉滴注与儿童清肺口服液联用治疗小儿呼吸道合胞病毒性肺炎痰热闭肺证的有效性和安全性。方法以利巴韦林注射液静脉滴注与复方愈创木酚磺酸钾口服液口服联用为对照,采用区组随机法将符合纳入标准的患儿分为中药治疗组(试验组)和西药对照组(对照组),在5个中心同时进行平行对照的临床试验,疗程为10天,疗效评价采用终点疗效评价方法和基于临床指标起效时间评价方法。结果两种疗效评价方法表明,试验组综合疗效优于对照组(P<0.05);试验组在主症发热、咳嗽、痰壅、肺部听诊、X线胸片等的疗效与起效时间方面均优于对照组,差异有统计学意义(P<0.05),且安全性评价良好。结论清开灵注射液静脉滴注配合儿童清肺口服液口服是一种治疗呼吸道合胞病毒性肺炎痰热闭肺证有效、安全的治疗方案。
Objective To study the effect and safety of the combination of Qingkailing Injection with Ertong Qingfei Oral Liquid for the treatment of accumulation of phlegm-heat in lung in children respiratory syncytial virus pneumonia （RSVP）. Methods The involved children were randomized into Chinese medicine treatment group and control group which was treated by Ribavirin Injection plus Gompound Guaiacol Potassium Sulfonale Oral Solution. The study was carried out simultaneously in five clinical centers in a dura- tion of l0 days. Endpoint evaluation and effect onset evaluation were adopted to determine the therapeutic effect. Results The effect of Chinese medicine treatment group was evaluated safe and better than that of control group with a significant difference （P〈0.05）. The effect onset of Chinese medicine was earlier than that of western medicine on relieving fever, cough, phlegm accumulation and on chest auscultation and X-ray manifestation （P〈0.05）. ConcLusion The combination of Qingkailing Injection with Ertong Qingfei Oral Liquid is a safe and effective therapy for the syndrome of accumulation of phlegm-heat in lung in children RSVP.
出处
《中医杂志》
CSCD
北大核心
2008年第7期602-604,共3页
Journal of Traditional Chinese Medicine
基金
“十五”国家科技攻关计划项目“中医药治疗病毒性肺炎疗效评价方法研究”(2004BA716B03)
关键词
呼吸道合胞病毒肺炎
痰热闭肺证
清开灵注射液
儿童清肺口服液
临床研究
Respiratory syncytial virus pneumonia
Syndrome of accumulation of phlegm-heat in lung, Qingkailing Injection, ErtongQingfei Oral Liquid, Clinical study
