摘要
目的研究青紫薯色素抗肿瘤作用并对其毒性进行安全性评价。方法以小鼠肉瘤S180瘤株和小鼠肝癌H22瘤株为实验对象,每日分别灌胃给予阳性药呋喃氟尿嘧啶及150、75和37.5mg的青紫薯色素,通过计算肿瘤抑制率观察青紫薯色素的体内抗肿瘤作用;通过亚慢性毒性试验以及骨髓微核试验、Ames试验对青紫薯色素进行毒理学评价。结果青紫薯色素灌胃,每日150、75mg剂量对小鼠肉瘤S180的抑瘤率分别为45.04%和36.64%,37.5mg剂量无抑瘤作用;青紫薯色素每日150mg剂量对小鼠肝癌H22有明显抑制作用,抑瘤率达33.33%;青紫薯色素1000mg/(kg.d)灌胃对大鼠未见明显毒性反应;在骨髓微核试验、Ames试验中均呈阴性结果。结论青紫薯色素对小鼠移植瘤有抑制作用,基本无毒性,无致突变作用。
Objective To investigate the antitumor effect and estimate the toxicity of Ipomoea Batatas Poir Cv anthocyanins. Methods Mice sarcinoma S180 and mice liver cancer H22 were administered with positive Ftorafur and different dose of Ipomoea Batatas Poir Cv anthocyanins by pouring into the stomach. The antitumor effects of Ipomoea Batatas Poir Cv anthocyanins were observed by calculating the inhibition rate. Subchronic toxicity tests and micronucleus test of bone marrow cell in mice and Ames test were carried out to evaluate the toxicity. Results At the doses of 150mg and 75mg Ipomoea Batatas Poir Cv anthocyanins, the rates of sarcinoma 180 inhibition were 45.04% and 36.64% respectively. The rate of liver cancer H22 inhibition at the dose of 150mg Batatas Poir Cv anthocyanins was 33.33%. The result of subchronic toxicity tests showed that Ipomoea Batatas Poir Cv anthocyanins had no obvious toxicity to rats. The results of the Ames test and micronucleus test were negative. Conclusion Ipomoea Batatas Poir Cv anthocyanins could have inhibitory effect on transplantation tumor of mice, and have no toxicity and no mutation.
出处
《卫生研究》
CAS
CSCD
北大核心
2008年第4期489-491,共3页
Journal of Hygiene Research
基金
山东省教育厅资助项目(NoJ04E17)
关键词
青紫薯色素
抗肿瘤
毒理学
Ipomoea Batatas Poir Cv anthocyanins, antitumor, toxicology
