摘要
以酮症起病的肥胖性糖尿病患者可能是2型糖尿病的一个亚型,其特点是起病急,以酮症为首发症状,发病前患者往往肥胖,有糖尿病家族史,但缺乏典型1型糖尿病的自身免疫证据;经用胰岛素控制血糖后,胰岛β细胞功能可不同程度的恢复等。由于此类酮症起病的肥胖糖尿病患者兼备1型和2型糖尿病的特点,目前对其诊断、分型以及治疗、预后评估尚无统一的意见,深入探讨其可能的病理生理机制的研究有助于为这部分患者最终的临床分型和制订正确有效的治疗方案提供依据。
Ketosis-prone diabetes mellitus （KPDM） may be a subtype of type 2 diabetes, characterized by fulminant onset, with diabetic ketoacidosis and usually obesity and over-weight, as well as a positive family history of diabetes, but lacking markers of autoimmunity observed in classic type 1 diabetes. Recovery of glucose homeostasis, accompanied by recovery of B-cell function, follows intensive glycemic regulation by insulin. Because of the mixed features of type 1 and type 2 diabetes, there is no completely agreement on diagnostic criteria and classification according to clinic presentation, metabolic and immunologic features of the novel atypical diabetes. Additional pathophysiological and genetic insight is therefore needed to provide a better understanding of the mechanisms of partially reversible insulin secretary defect in such syndrome, which is critical for its clinical classification and the development of appropriate treatment strategies.
出处
《医学研究生学报》
CAS
2008年第7期758-762,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金资助项目(批准号:0040205401169)
关键词
糖尿病
酮症
诊断
Diabetes mellitus
Ketosis
Diagnosis
