摘要
目的比较双铂方案(卡铂+顺铂+5-氟脲嘧啶,CPF方案)治疗晚期食管癌的疗效与毒副反应,探讨应用双铂方案一线治疗晚期食管癌的可能性。方法采用随机对照研究,158例食管癌按照2∶1随机分组,98例进入双铂方案组(卡铂300 mg/m2ivgttd1,顺铂25 mg/m2ivgtt d2-5,5-Fu 500 mg/m2ivgtt d1-4,21d为1周期);60例进入PF方案组(顺铂40 mg/m2ivgtt d1-3,5-Fu 1 000mg/m2civ d1-4,21 d为1周期),观察和比较两组的毒副反应、近期疗效和远期生存率。结果双铂方案组近期有效率(CR+PR)72.45%(71/98);PF方案组近期有效率(CR+PR)51.67%(31/60),两组比较差异有统计学意义(P=0.010)。双铂方案组中的1年生存率为58.16%(57/98),PF组1年生存率为40.00%(24/60),两组比较差异有统计学意义(P=0.033)。双铂方案组血液学毒性较为明显但可以耐受。结论双铂方案治疗晚期食管癌疗效较好,值得推荐至一线应用。
Objective To Compare the efficacy and toxicity of CPF regimen and PF regimen in the treatment on patients whit mediated-advanced esophageal cancer. To approach the possibility of CPF regimen for first-line treatment in mediated-advanced esophageal cancer. Meth- ods From October 2000 to June 2006, the 158 cases with esophageal cancer were randomly grouped. 98 cases were treated with CPF regi- men; 60 cases were treated with PF regimen. To observe the recent efficacy, toxicity and survival rate. Results The total response rate （ CR ＋ PR） in CPF regimen and PF regimen groups were 72.45 % （71/98 ） and 51.67 % （ 31/60） respectively. Significant difference was observed between CPF regimen group and PF regimen group（P =0. 010）. 1 year survival rates were 58.16% , 40.00% , respectively in CPF regimen group and PF regimen group in turn, but significant difference was observed between CPF regimen group and PF regimen group（ P = 0. 033）. The main toxicity of CPF regimen group was myelosuppression. Conclusion The combined chemotherapy regimen CPF is beneficial for esopageal cancer.
出处
《肿瘤基础与临床》
2008年第4期310-312,共3页
journal of basic and clinical oncology
基金
河南省2005年攻关课题(编号:0524410002)
河南省科技人才创新工程2004年资助项目(豫卫科[2004]21-89)
