摘要
目的探讨GLUT1表达与口腔鳞状细胞癌发生、发展及其生物学行为的关系。方法应用免疫组化S-P法检测52例口腔鳞状细胞癌组织及其癌旁不典型增生组织、切缘正常黏膜组织中GLUT1的表达。结果免疫组化阳性信号定位于细胞膜中,GLUT1在口腔鳞癌组织、癌旁不典型增生组织及正常口腔黏膜组织中的阳性表达率分别为88.46%、54.84%和19.23%,3组间两两比较,差异均有统计学意义(P<0.01)。结论GLUT1可能参与了口腔鳞状细胞癌的发生和发展过程。
Objective To study the relations between the expressions of GLUT1 to the occurrence, development or biology behaviors of human oral squamous cell carcinoma（OSCC）. Methods Immunohistochemistry S-P method was used to detect the expression of GLUT1 in 52 cases of OSCC tissues, the tissues of atypical hyperplasia of tumor-adjacent and normal oral mucosa. Results The positive signal of GLUT1 protein was located in cell membrane, the positive rate of its expressions was high, low and lower respectively in the tumor tissues, the tissues of atypical hyperplasia of tumor-adjacent and normal oral mucosa （88, 46% , 54.84% and 19.23% ）. There was a significant difference in the expressions of GLUT1 among the three groups （P 〈0.01 ）. Conclusion The GLUT1 protein might serve as a significant predicting factor for proliferative status of carcinoma cell.
出处
《肿瘤基础与临床》
2008年第4期301-302,共2页
journal of basic and clinical oncology
