摘要
目的:探讨粒细胞肉瘤(granulocytic sarcoma,GS)的组织学特征及免疫组化诊断。方法:对7例GS的组织形态学及免疫组织化学特征进行回顾性分析。结果:GS组织学上表现为弥漫分布、形态相对一致的分化较差细胞,小至中等大小,胞质少,胞核呈圆形、卵圆形,染色质细腻。免疫组化染色显示,髓过氧化物酶(MPO)表达6例,CD43表达6例,CD68表达5例,CD99表达4例,CD34表达3例,CD15表达1例。结论:GS在常规石蜡包埋切片上的形态学特点与恶性淋巴瘤极其相似,易造成误诊。联合使用MPO、CD68、CD43、CD34、CD99等多种粒系抗体进行免疫表型的检测可使绝大多数GS得到确诊。
Objective：To study the histological features and immunohistochemical diagnosis of granulocytic sarcoma. Methods： The morphological and immunohistochemical featrures were retrospectivelly analyzed in 7 cases of granulocytic sarcoma. Results：Histo-logically, the GS were composed of a relatively uniform population of poorly differentiated cells growing in a diffuse pattern and were small to medium in size, with scant cytoplasm. The nuclei were round and oval, and had finely dispersed chromatin. Immunohisto-chemistry study showed that 6 cases were positive for MPO and CD43, 5 cases for CD68, 4 cases for CD 99, 3 cases for CD34 and CD43. Conclusions： Granulocytic sarcomas are morphologically analogous to malignant lymph oma in routine paraffin-embedded tissue sections and may be frequently misdiagnosed. Immunohistochemistry panel of granulocytic makers such as MPO ,CD68 ,CD43 ,CD34, CD99 can successfully identify the vast majority of GS.
出处
《赣南医学院学报》
2008年第3期335-337,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
粒细胞
肉瘤
免疫组织化学
病理学
Granulocytic
sarcoma
immunohistochemtry
pathology
