摘要
目的比较艾司西酞普兰与文拉法辛治抑郁症的疗效和安全性。方法将48例抑郁症患者随机分为两组,分别给以予艾司西酞普兰与文拉法辛治疗,疗程6周。用汉密尔顿抑郁量表(HAMD)在治疗前及治疗1、2、4、6周评定疗效;用副反应量表(TESS)评定不良反应。结果两组总体疗效相当,艾司西酞普兰组HAMD评分从第1周就开始显著下降,而文拉法辛组HAMD评分从第2周开始显著下降;治疗6周艾司西酞普兰组有效率95%,显效率77%,文拉法辛组分别为88%和69%。两组不良反应均较轻,安全性好。结论艾司西酞普兰与文拉法辛均是安全有效的抗抑郁药。
Odjective To explore clinical efficacy and safety of escitalpram and ,venlafaxine in the treatment of depression. Methods Forty eight patients with depression were treated randomly with escitalopram or venlafaxine for a treatment of six weeks ,and measured with Hamilton Depressive Scale （HAMD）,and Treatment Emergent Symptom Scale （TESS） before treatment and 1,2,4,6 weeks after treatment. Results There wss no significant difference in efficacy between two groups. HAMDscores decreaed dramatically at the end of 1st week in eseitalopram group and 2nd week in venlafaxine group. The rates of efficacy and marked improvement in eacitalopram group and venlafaxine group were 95% and 77%,88% and 69%. The side effects of both were fewer. Conclusion Escitalopram and venlafaxine are both effective and safe antidepressants.
出处
《精神医学杂志》
2008年第4期271-272,共2页
Journal of Psychiatry
