摘要
目的:探讨缺氧诱导因子-1α(HIF-1α)在稽留流产中的作用。方法:经B超及β-hCG动态监测证实为稽留流产患者50例,其中不明原因组30例,有原因组20例;根据胚胎停止发育后稽留宫内时间不同又分为A组、B组和C组,分别为胚胎停止发育≤2周、3-4周和≥5周。选取同时期经B超证实为活胎,因非意愿妊娠在门诊要求行人工流产的早孕妇女20例为对照组。应用免疫组织化学方法比较各组绒毛组织中HIF-1α的表达。结果:HIF-1α的表达主要位于绒毛滋养细胞胞浆和胞核;与正常早孕妇女绒毛组织相比较,稽留流产患者绒毛组织中HIF-1α表达明显降低(P<0.05);但A、B、C组间HIF-1α表达无统计学差异(P>0.05)。结论:HIF-1α在绒毛组织中的低表达可能是导致稽留流产的原因之一。
Objective：To explore the effect of hypoxia-inducible factor-1α （HIF-1 α） in villi of missed abortion patients. Methods： The expression of HIF-1α was detected in villi of missed abortion patients （known factor group, 20 cases; unknown factor group, 30 cases）, and normal early pregnant women （control group, 20 cases） by immunohistochemistry. The expression of HIF-1 α was analyzed in villi of missed abortion patients with different time that stayed in urine after the embryo died. Results： The expression of HIF-1α in villi of missed abortion patients was lower than that in normal early pregnant woman （P〈 0.05）. There was no difference of expression of HIF-1α in villi among groups with different time that stayed in urine after the embryo died. Conclusion： The low expression of HIF-1α in villi is a factor related with missed abortion.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2008年第7期415-418,共4页
Reproduction and Contraception
