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糖尿病和甲状腺功能亢进症阴虚证患者血清一氧化氮合酶活性的研究

Research on the NOS Activity Level in the Serum of Patients with Yin Deficiency Syndrome of NIDDM and Hyerthyroidism
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摘要 目的通过对2型糖尿病阴虚证患者、甲亢病阴虚证患者血清一氧化氮合酶(NOS)活性的检测,探讨NOS活性与阴虚证的关系及意义。方法分别检测2型糖尿病阴虚证患者、甲亢病阴虚证患者及正常对照组血清NOS的含量,并进行统计学分析。结果糖尿病阴虚证患者、甲亢病阴虚证患者NOS均显著高于正常对照组,而阴虚证两组间无显著差异。结论2型糖尿病和甲亢病患者的NOS可能对阴虚证有重要意义,NOS活性增强可能是阴虚证的病理基础之一。 Objective To study the pathological foundation and essence of Yin deficiency syndrome in TCM by investigating the activity of nitric oxide synthase (NOS) of the patients diagnosed as Yin deficiency syndrome in both non - insulin - dependant diabetes mellitus (NIDDM) and hyperthyroidism. Methods The activity of serum NOS was detected in Yin deficiency syndrome patients of NIDDM, Yin deficiency syndrome patients of hyperthyroidism and control group, respectively. The students' test was adopted for statistical analysis. Results The serum NOS activity in the cases of both NIDDM - Yin deficiency group and hyperthyroidism - Yin deficiency group were higher than that in control group( P 〈0.05 ) , however, there was no significant difference between NIDDM - Yin deficiency group and hyperthyroidism - Yin deficiency one. Conclusion NOS activity in the patients suffered from NIDDM and hyperthyroidism is possibly significant with Yin deficiency syndrome, higher activity of NOS may be the one of the pathological foundations of Yin deficiency syndrome.
机构地区 湖北中医学院
出处 《时珍国医国药》 CAS CSCD 北大核心 2008年第5期1112-1113,共2页 Lishizhen Medicine and Materia Medica Research
关键词 糖尿病 甲状腺功能亢进症 阴虚证 一氧化氮合酶 Diabetes mellitus (DM) Hyerthyroidism Yin deficiency syndrome Nitric Oxide Synthase (NOS)
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  • 1Busse R,Minlsch A,Fleming F,et al.Mechanism of nitric oxide release from the vascular endothelium.1993,87(Suppl Ⅴ):18. 被引量:1
  • 2中华人民共和国卫生部药政局.中药新药临床研究指导原则:第1辑[S].1993.158-170 被引量:2
  • 3Moncada S,Palmer RM J,Higgs EA,et al.Nitric oxide:physiogy,pathophysiology,and pharmacolgy[J].Pharmacological Reviews,1991,43(2):109. 被引量:1

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