摘要
目的探讨低氮低热卡肠外营养支持联合重组人生长激素(rhGH)在重度腹部创伤中的早期应用对患者蛋白质代谢和免疫功能的影响及临床意义。方法选择68例重度腹部创伤患者,随机分为低氮低热卡肠外营养联合rhGH组(n=34)和低氮低热卡肠外营养对照组(n=34),分别接受低氮低热卡肠外营养联合rhGH和低氮低热卡肠外营养治疗,观察两组的血糖、甘油三脂(TG)、蛋白质代谢指标、免疫指标和并发症的变化情况。结果与对照组相比,低氮低热卡肠外营养联合rhGH组,治疗后第4、7天蛋白质代谢指标、免疫指标明显改善,术后并发症的发生率明显降低(P<0.05)。而两组血糖和TG在治疗前和治疗后4d、7d监测显示,两组间差异无统计学意义(P>0.05)。结论重度腹部创伤早期低氮低热量联合rhGH肠外营养支持是一种安全有效代谢调理治疗措施,能明显改善患者的预后,有利于患者的康复。
Objective To observe the effects of hypocaloric and lower nitrogen parenteral nutrition combined with recombinant human growth hormone （fhGH） support on immunologic function and protein metabolism in early severe abdominal trauma and clinical significance. Methods Sixty - eight cases of severe abdominal trauma were randomly divided into control group （ n = 34） and study group （ n = 34）, treated with hypocaloric and lower nitrogen parenteral nutrition, and hypocaloric and lower nitrogen parenteral nutrition combined with rhGH, respectively. The blood glucose level, TG,indexes of protein metabolism,immune indexes and complications were analyzed. Results Indexes of protein metabolism and immune indexes in study group were obviously improved as compared with control group on the day 4 and 7 after the treatment （ P 〈 0.05 ）, and the incidence of complications in study group was lower than in control group （P 〈 0.05）. However,there was no significant difference in the blood glucose level and TG before and 4,7 days after the treatment （ P 〉 0.05）. Conclusion The hypocaloric and lower nitrogen parenteral nutrition support combined with rhGH is a safe and effective method for postoperative support in severe abdominal trauma and it can improve prognosis and is beneficial to the rehabilitation of the patients.
出处
《临床外科杂志》
2008年第7期467-469,共3页
Journal of Clinical Surgery
关键词
低氮
低热卡
胃肠外营养
生长激素
腹部创伤
lower nitrogen
hypocalorie
parenteral nutrition
rhGH
abdominal trauma
