摘要
目的了解孕前妇女TORCH感染情况,对筛查出的风疹病毒抗体阴性者,通过注射风疹疫苗,获得主动免疫后再怀孕,对弓形虫抗体阳性,巨细胞病毒,单纯疱疹病毒及其他病毒感染者,转诊到相关医疗单位进行治疗,以减少缺陷儿的出生。方法采用生物芯片技术对20000例孕前妇女的血清进行TORCH病原体IgM检测。结果TORCH-IgM总阳性1784例、阳性率8.92%,单项病原体感染1395例、阳性率6.98%,合并感染(两种以上病原体)389例、阳性率1.95%。总Tox-IgM阳性419例、阳性率2.09%,RuV-IgM阳性825例、阳性率4.13%,CMV-IgM阳性423例、阳性率2.12%,HSV-I-IgM阳性422例、阳性率2.11%,HSV-Ⅱ-IgM阳性233例、阳性率1.17%。结论孕前妇女TORCH检测对预防宫内感染和畸形胎儿出生,提高出生人口素质具有非常重要的意义,建议将TORCH检测作为孕前常规检查项目。
Objective ： To understand the prevalence of TORCH infection in pre - pregnant women, so as to provide active immunotherapy to those with negative RV antibodies by RV vaccination, give pre - pregnancy treatment to those infected with TOX, CMV, HSV or other virus and to reduce the number of abnormal fetuses. Methods： Serum samples from 20 000 pre - pregnant women were deterrdined for TORCH special IgM antibodies by microarray technique. Results： The total positive rate of TORCH was 8. 92% （ 1784/ 20000）, while those of TOX, RV, CMV, HSV -Ⅰ and HSV -Ⅱ were 2.09% （419/20000）, 4. 13% （825/20000） , 2. 12% （423/ 20000） , 2. 11% （422/20000） and 1.17% （233/20000） , respectively. Conclusion： Pre - pregnancy examination for TORCH infection is of important significance for the prevention of intrauterine infection and abnormal fetuses, as well as for the improvement of the neonatal population quality.
出处
《中国优生与遗传杂志》
2008年第7期97-99,共3页
Chinese Journal of Birth Health & Heredity
基金
江苏省出生缺陷干预工程资助项目(项目号JS2003-02)
