摘要
为探讨内皮素在妊高征发病机理中的作用，对15例妊高征及15例正常孕晚期病例测定产前血浆内皮素水平及应用离体脐带血管内皮细胞培养后测定内皮素含量，发现重度妊高征产前血浆内皮素及脐带内皮细胞培养中的内皮素值明显高于轻、中度及正常孕妇（均为P＜0．05）。内皮素值与妊高征病情呈正相关。离体脐带血管内皮细胞培养的内皮素值高于血浆水平。结果表明：离体脐带血管内皮细胞培养的内皮素变化更进一步证实妊高征子宫胎盘组织的缺血缺氧及内皮细胞损伤与妊高征发生、发展密切相关。内皮素的测定可作为判断妊高征病情严重程度的重要临床参数。
To evaluate the value of endothelin(ET) in pathogenesis with pregnancy-inducedhypertension(PIH). Methods: The concentrations of ET in plasma of late pregnant women and in umbilical bloodendothelial cell culture in vitro were detected by radioimmunoassay respectively (15 cases with PIH and 15normal pregnancy). Results: The level of ET was significantly higher in severe PIH than in moderate, mild PIHand normal cases (P<0. 05). The level of plasma ET was correlated with the seventy of PIH. Theconcentration of ET in vitro cluture was higher than that in plasma. Conclusions: The changes of ET in umbilicalblood endothelial cell culture in vitro indicate that the shortage of blood and oxygen in utero-placental tissuesas well as endothelial cell injury may play an important role in the pathogenesis of PIH. The detection of ETis a valuable parameter to determine the clinical seventy of PIH.
出处
《同济医科大学学报》
CSCD
1997年第6期463-465,共3页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金!39170758
