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心力衰竭引起骨骼肌病变的分子机制 被引量：2

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摘要 骨骼肌病变是慢性心力衰竭的主要症状之一。引发骨骼肌细胞结构和功能异常的确切机制尚不清楚。本文介绍了近年来发现的相关分子机制,主要包括肌抑素、胰岛素样生长因子-1、部分致炎细胞因子、过氧化物增殖激活受体γ协同激活子-1α、MAFbx泛素连接酶和Bcl-2家族蛋白等活性分子的发病学意义。对这些活性分子的研究,为心力衰竭临床治疗和改善预后提供了新的思路。
作者 黄慧雅 陈骏良 方艳 常冬元 胡向欣 李葚煦 唐朝枢
机构地区 北京大学医学部生理学系
出处 《国际心血管病杂志》 2008年第4期218-221,共4页 International Journal of Cardiovascular Disease
关键词 心力衰竭 骨骼肌病变 生物活性分子
分类号 R541.61 [医药卫生—心血管疾病]
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参考文献22

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二级参考文献72

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共引文献8

同被引文献31

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引证文献2

二级引证文献15

国际心血管病杂志
2008年 第4期

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