摘要
目的比较常规分割放疗与常规分割放疗协同替加氟治疗食管癌的疗效与毒性。方法将100例胸段食管鳞癌患者随机分为2组：常规分割组（CF组）为每周照射5次,2.0Gy/次,总量64~70Gy;常规分割＋替加氟组（CF＋H组）：在常规分割放疗开始之日起加用替加氟静脉滴注,0.5g/天,共10天。结果CF组和CF＋H组半年、1年、2年、3年生存率分别为60.0%和80.0%、54.0%和78.0%、30.0%和56.0%、18.0%和40.0%;半年、1年、2年、3年的局部控制率分别为68.0%和86.0%、40.0%和74.0%、32.0%和64.0%、24.0%和44.0%。CF＋H组的生存率和局部控制率均明显高于CF组（P〈0.05）。2组患者的死亡原因无明显差异,但CF＋H组患者死于局部复发的低于CF组。结论常规分割放疗协同替加氟治疗能提高食管癌的局部控制率与生存率。
Objective To compare the treatment effects and toxicity of conventional fractionation radiotherapy（CF） and CF plus ftorafur concurrent chemotherapy（CF＋H） on esophageal cancer.Methods 100 patients with squamous carcinoma of thoracic esophagus were divided randomly into two groups：CF group,patients were irradiated 2.0 Gy/f,5 times a week,to total does of 64～70 Gy;CF＋H group,the radiotherapy technique was the same as the CF group,but 0.5 g ftorafur（FT-207） was added for 10 days when the radiotherapy was begun.Results All two groups completed their treatment course.Of CF and CF＋H groups,the 0.5-,1-,2-and 3-year survival rates were 60.0% and 80.0%、54.0% and 78.0%、30.0% and 56.0%、18.0% and 40.0%.The 0.5-,1-,2-and 3-year local control rates were 68.0% and 86.0%、40.0% and 74.0%、32.0% and 64.0%、24.0% and 44.0%,with obvious better results in CF＋H group（P〈0.05）.The acute tracheitis and the toxic effect of stomach and intestines in the acute toxic effect was severer in the CF＋H group than in the CF group（P〈0.05）.There were no significant differences in causes of death between the two groups.The main cause of death was local recurrence and uncontrolled primary disease,which was significantly lower in the CF＋H group than in the CF group.Conclusion Conventional fractionation radiotherapy plus ftorafur concurrent chemotherapy can significantly improve the local control and survival of esophageal cancer,but toxicity was increased.
出处
《实用癌症杂志》
2008年第4期378-380,共3页
The Practical Journal of Cancer
关键词
食管肿瘤
放射疗法
化学疗法
预后
Esophageal neoplasm
Radiotherapy
Chemotherapy
Prognosis
