摘要
γ-突触核蛋白基因（γ-synuclein，SNCG），又称乳腺癌特异性基因1（breast cancer specific gene1，BCSG1），由Ji等于1997年发现，与已知的α-和β-突触核蛋白同属突触核蛋白基因家族。对突触核蛋白家族的研究一直是神经变性疾病领域的热点，它的表达异常影响多巴胺能神经元功能，导致阿尔茨海默病和帕金森病等神经退行性疾病的发生和发展。近期研究发现突触核蛋白家族与肿瘤遗传学相关，尤其是其中最后发现的SNCG与多种器官恶性肿瘤的发生和进展有关。在乳腺癌中，SNCG可能与肿瘤发生、进展、转移以及化疗耐药关系密切。
出处
《中华外科杂志》
CAS
CSCD
北大核心
2008年第14期1110-1111,共2页
Chinese Journal of Surgery
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引证文献2
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