摘要
目的探讨甘肃武威地区汉族人口非酒精性脂肪肝(NAFLD)的临床特点和相关危险因素。方法运用回顾性分析结合多元Logistic回归分析,探讨2003年3月～2006年3月武威市人民医院门诊体检的180例武威地区汉族人口NAFLD的临床特点和相关危险因素并与180例正常对照组进行比较。结果NAFLD组血清ALT和AST异常率均高于对照组,其中又以ALT异常率的增高更加明显。与对照组相比,易伴发肥胖、Ⅱ型糖尿病、心脑血管疾病、高脂血症等疾病。体重指数(BMI)、舒张压(DBP)、高脂饮食、甘油三脂(TG)和载脂蛋白B(ApoB)与NAFLD的发生呈负相关关系,高密度脂蛋白(HDL)与NAFLD的发生呈正相关关系。结论BMI、DBP、高脂饮食、TG和ApoB为NAFLD的独立危险因素,HDL为其保护因素。定期体检、控制血脂水平、改善原有的不良饮食结构、加强锻炼、控制体重为预防NAFLD及其伴发疾病的重要措施。
Objective To investigate the clinical features and related risk factors for nonalcoholic fatty liver disease （NAFLD） in Wuwei area. Methods Retrospective case-control study was performed to explore the clinical features and related risk factors for NAFLD by Logistic regression analysis. Results Level of serum ALT increased significantly in the patients with NAFLD and was 2-fold higher than that of the normal limit;serum AST increased mildly. Obesity, type 2 diabetes mellitus, heart and brain blood vesseldisease and hyperlipidemia were syndromes of NAFLD. BMI, DBP, high lipid food, serum TG, serum ApoB were negatively correlated with the occurrence of NAFLD, while serum HDL was positively correlated with the occurance of NAFLD. Conclusion BMI, DBP, high lipid food, serum TG and serum ApoB may be independent risk factors for NAFLD, while serum HDL is prepective factor of NAFLD. To prevent NAFLD and its syndromes, periodical physical examination, changing unhealthy life styles and controlling obesity are the most important.
出处
《临床消化病杂志》
2008年第3期140-142,共3页
Chinese Journal of Clinical Gastroenterology
关键词
非酒精性脂肪肝
临床
危险因素
Nonalcoholic fatty liver disease
Clinic
Risk factor
