摘要
目的探讨在空气加压氧舱中新生儿缺氧缺血性脑病的治疗方法及其疗效。方法将缺血缺氧性脑病患儿142例分为高压氧＋药物多疗程序贯治疗组（序贯治疗组，n=70）、高压氧＋药物单疗程治疗组（单疗程组，n=39）和单纯药物治疗组（药物治疗组，n=33）。3组患儿均采用常规药物治疗，而序贯治疗组和单疗程组在常规药物治疗的基础上另在大型空气加压舱中，采用改良封闭式吸氧头罩＋2．5L呼吸球囊连续供氧方式进行高压氧治疗，序贯治疗组连续治疗3个疗程，单疗程组仅治疗1个疗程。3组患儿均于3，6和12月龄时行智能和运动发育评估，另于12月龄时行头颅CT复查。结果智能发育评分序贯治疗组显著高于单疗程组和药物治疗组（P〈0．05）；单疗程组与药物治疗组比较差异无统计学意义（P〉0．05）。头颅CT复查显示，12月龄时药物治疗组异常率显著高于序贯治疗组（P〈0．05），与单疗程组比较，差异无统计学意义（P〉0．05）。结论在空气加压舱中使用改良的封闭式输氧头罩，以高压氧加药物多疗程序贯治疗比单程高压氧或单纯药物治疗能取得更为显著的疗效。
Objective To observe the efficacy, benefits and shortcomings of pressurized air therapy for neonatal hypoxic ischemic encephalopathy （HIE）. Methods One hundred and nine neonates with HIE were treated with hyperbaric oxygen （HBO） with a continuing oxygen supplement from an improved oxygen mask plus a 2.5-litre breathing sacculus proprius in a large air-pressurized oxygen chamber. Among them there were 70 cases treated with 3-6 courses of HBO ＋ drug therapy, 39 cases treated with a single session of HBO ＋ drug therapy, and 32 treated with drug therapy alone. Motor development was assessed using the Chinese infantile intelligence development test scale at the ages of 3, 6 and 12 months. Results The sequential HBO ＋ drug group achieved significantly better average motor development than the single session group or the drug only group. There was mo significant difference between the single treatment group and the drug only group. The proportion of abnormal CT results 12 months after treatment was significantly higher in the drug only group than in the sequential HBO ＋ drug group. Conclusion Sequential HBO ＋ drugs therapy with the improved oxygen mask is preferable to a single session of HBO ＋ drug treatment or drug therapy alone.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2008年第6期406-409,共4页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
新生儿
缺氧缺血性脑病
高压氧
空气加压舱
输氧头罩
Neuonates
Hypoxic ischemic encephalopathy
Hyperbaric oxygen
Air-pressurized chambers
Oxygen masks
