摘要
恶性肿瘤严重危害着人类的健康.尽管肿瘤的病因学研究取得了一定进展,肿瘤的临床处置依然面临挑战,包括手术切除、化学药物治疗和放射治疗在内的标准治疗模式不能对所有患者都奏效.如何选择合适的治疗方案和准确评估患者的预后,临床医生经常感到困惑.针对信号通路重要蛋白的分子靶向治疗的结果显示,不同肿瘤患者具有独特的分子表型特征并决定了肿瘤治疗的疗效.有效治疗肿瘤需要量体裁衣式地设计出个体化的治疗方案.通过"组"学研究发现了许多肿瘤细胞特异的分子表型,而针对这些表型的个体化治疗将是未来肿瘤治疗的方向.
Malignant tumor impairs human’s health severely. Although progresses have been made in tumor’s etiology, clinical management of tumor is still confronted by challenges. The standard treatments against tumor, including surgery, chemotherapy and radiotherapy, are not effective for all patients. The clinicians often feel confused while selecting appropriate therapeutic pattern and judging patients’ prognosis. The clinical outcome of target-protein-based cancer therapy revealed that personalized molecular signature determined individualized curative effect. Effective management of tumor needs patient-tailored design. The so-called ＂omic＂ researches accelerate the studies in specific molecule phenotype of tumor cells, and the personalizedtherapy against such individualized malignant phenotype will represent the future direction in tumor treatment.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第16期1781-1787,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30772507
No.30721001
国家重点基础研究发展规划资助项目
No.2004CB518707
高技术发展计划"863"资助项目
No.2006AA02Z19B~~
关键词
分子表型
个体化治疗
蛋白质组学
肿瘤标志
信号通路
Molecular phenotype
Personalized therapy
Proteomics
Tumor marker
Signaling pathway
