摘要
目的:探讨北柴胡对对乙酰氨基酚所致小鼠急性肝损伤的保护作用。方法:采用0.5 g·kg^(-1)对乙酰氨基酚灌胃造模,以血清中天冬氨酸氨基转移酶(AST),丙氨酸氨基转移酶(ALT),血清碱性磷酸酶(ALP),肿瘤坏死因子(TNF-α)含量为指标,观察北柴胡醇提物及北柴胡水提物对肝损伤的保护作用。结果:北柴胡醇提物及北柴胡水提物均能不同程度降低血清中AST,ALT,ALP和TNF-α含量,与水飞蓟素无明显差别。结论:北柴胡对对乙酰氨基酚所致小鼠急性肝损伤有一定的保护作用。
Objective： To observe the protective effect of Bupleurum Chinese Dc against acute liver injury induced by acetaminophen （AAP） in mace. Method： Paracetamol was irritated the stomach of mice to make models with the dose of 0.5 g·kg^-1. Compared to the index of the content of serum AST, ALT, ALP and TNF-α of the evened liver liquid, the protective effect of Bupleurum Chinese Dc ethanol extraction and Bupleurum Chinese Dc water extraction was observed. Result： Bupleurum Chinese Dc ethanol extraction and Bupleurum Chinese Dc water extraction both can distinctly decrease the content of serum AST, ALT, ALP and TNF-α of the evened liver liquid. The protective effect of liver was identical to that of silymarin. Conclusion： Bupleurum Chinese Dc have certain protective effect against acute liver injury induced by acetaminophen（AAP）.
出处
《中国药师》
CAS
2008年第7期747-749,共3页
China Pharmacist
基金
吉林省杰出科技青年资助项目(编号:5-28-17)
关键词
北柴胡
对乙酰氨基酚
水飞蓟素
肝损伤
Bupleurum Chinese Dc
Acetaminophen （AAP）
Silymarin
Liver injury
