摘要
目的考察五水头孢唑啉钠与奥硝唑配伍的稳定性。方法在室温下(25℃)观察8h内注射用五水头孢唑啉钠(51mg/L)与奥硝唑氯化钠注射液(20mg/L)配伍液的pH值、外观及紫外光谱的变化,用紫外双波长分光光度法及系数倍率法分别测定五水头孢唑啉钠与奥硝唑的含量。结果五水头孢唑啉钠与奥硝唑配伍液的pH值、外观、含量无明显变化。结论注射用五水头孢唑啉钠与奥硝唑氯化钠注射液的配伍液在25℃下、8h内可配伍使用。
Objective To study the compatible stability of cefazolin sodium pentahydrate with Omidazole Sodium Chioride Injection. Methods At the room temperature（25℃ ）, the changes in pH value, appearance and UV spectrophotometry of the mixed liquid of cefazolin sodium pentahydrate with Omidezole Sodium Chloride Injection were observed within 8 h, at the same time, the content of both constituents were determined by dual ultraviolet wavelength spctrophotometry and K- ratio spectrophotometry. Results The mixed liquid of cefazolin sodium pentahydrate and Omidazole Sodium Chloride Injection had no evident variation in, pH value, appearance and content at 25℃ within 8 h. Conclusion Cefazolin sodium pentahydrate can be compatibly mixed with omidazole sodium chioride at 25℃ within 8 h.
出处
《中国药业》
CAS
2008年第14期27-28,共2页
China Pharmaceuticals
关键词
五水头孢唑啉钠
奥哨唑氯化钠注射液
配伍
稳定性
cefazolin sodium pentahydrate
Omidazole Sodium Chioride Injection
combination
compatible stability
