摘要
采用原子吸收分光光度法测定了４０例宫颈癌，３０例子宫肌瘤组织和血清中Ｃｕ、Ｚｎ、Ｆｅ、Ｍｎ、Ｃａ和Ｓｒ的含量。结果表明，宫颈癌组织和血清中Ｃｕ、Ｆｅ含量和Ｃｕ／Ｚｎ比值明显高于非病变组织和健康人（Ｐ＜０．００１），而Ｚｎ、Ｃａ、Ｍｎ和Ｓｒ含量明显低于非病变组织，Ｚｎ、Ｃａ含量明显低于健康人血清（Ｐ＜０．０２～Ｐ＜０．００１）。子宫肌瘤组织中Ｆｅ含量和血清中Ｃｕ／Ｚｎ比值高于非病变组织和健康人血清（Ｐ＜０．００１），而组织中Ｚｎ和血清中Ｚｎ、Ｆｅ、Ｃａ含量明显低于非病变组织和健康人血清（Ｐ＜０．００１）。宫颈癌患者血清中Ｃｕ含量、Ｃｕ／Ｚｎ比值和癌组织中Ｃｕ／Ｚｎ明显高于肌瘤患者血清及肌瘤组织（Ｐ＜０．０１～Ｐ＜０．００１）。经ｌｏｇｉｓｔｉｃ多元逐步回归分析，血清中Ｃｕ含量较高者，发生宫颈癌的危险度较高，患者血清中Ｚｎ和组织Ｓｒ含量较高者，发生宫颈癌的危险度较低，Ｃｕ可能是诱发宫颈癌的危险因素。Ｚｎ、Ｓｒ可能是宫颈癌的保护因素。此外，血清中Ｃｕ／Ｚｎ比值测定对宫颈癌诊断阳性率为７２％，可作为宫颈癌诊断、鉴别指标之一。
Zinc,copper,iron,manganese,calcium and strontium levels in the tumor tissue and serum by atomic absorption spectrophotometry in 40 patients with cervix cancer and 30 patients with myoma of uterus were determined.The results showed that in serum and malignent tissue of patients with cervix cancer,copper,iron levels and Cu/Zn ratio were significantly higher and zinc,manganese,calcium were significantly lower than those in healthy subjects serum and normal tissue (P<0.02—<0.001).In benign tissue of patients with uterus myoma iron was significantly higher and zinc was significantly lower;serum Cu/Zn ratio was significantly higher and zinc,iron,calcium were significantly lower than those in normal tissue and healthy subject serum(P<0.001).In malignant tissue Cu/Zn ratio and in serum copper,Cu/Zn ratio were significantly higher,zinc was significantly lower than those in benign tissue and serum (P<0.01—P<0.001).Multi-variable logistic regression analysis showed that serum copper elevation may be the dangerous factor,serum zinc.tissue strontium may be the protective factors of cervix cancer.Cu/Zn ratio had a sensitivity of 72% for the diagnosis of cervix cancer.The finding suggested that Cu/Zn ratio may be used as a diagnostic index in patients with cervix cancer.
出处
《营养学报》
CAS
CSCD
北大核心
1997年第4期401-404,共4页
Acta Nutrimenta Sinica
关键词
宫颈癌
子宫肌瘤
微量元素
cervix cancer myoma of the uterus trace element serum tissue
