摘要
设计合成含多个配位中心的多吡啶配体ODCIP(3,4-二氯基苯并咪唑并[4,5-f][1,10]邻菲咯啉)及其钌(Ⅱ)多吡啶配合物[Ru(bpy)2ODCIP]2+.运用元素分析、红外光谱、核磁谱和质谱对配体及配合物进行结构表征.利用紫外吸收光谱、荧光光谱和粘度法研究了[Ru(bpy)2ODCIP]2+与DNA(脱氧核糖核酸)的作用机制、与Co2+配位后与DNA的作用机制及其荧光变化情况.结果表明[Ru(bpy)2ODCIP]2+与DNA通过部分插入模式作用,[Ru(bpy)2ODCIP]2+与Co2+配位形成的双核配合物[Ru(bpy)2(ODCIP)Co]4+也能与DNA插入结合.进一步利用稳态荧光发射光谱、荧光淬灭实验等方法研究了单核配合物[Ru(bpy)2ODCIP]2+和双核配合物[Ru(bpy)2(ODCIP)Co]4+的荧光性质.
The polypyridyl ligand with multi coordination sites ODCIP （ODCIP = 3,4-dichloroimidazo[4,5-f][1,10]phenanthroline） and its ruthenium（Ⅱ） complex [Ru（bpy）2ODCIP]^2＋ were synthesized and characterized by elemental analyses, IR, NMR and FAB-MS, The DNA-binding properties of complex [Ru（bpy）2ODCIP]^2＋ were studied by absorption spectra, fluorescent spectra and viscosity methods. The coordination of [Ru（bpy）2ODCIP]^2＋ with Co^2＋ was also investigated. The results indicated that [Ru（bpy）2ODCIP]^2＋ bound to DNA by part intercalation. The binuclear complex [Ru（bpy）2（ODCIP）Co]^4＋ could be formed by [Ru（bpy）2ODCIP]^2＋ and Co^2＋, and it bound to DNA by intercalation. Furthermore, the luminescent properties of [Ru（bpy）2ODCIP]^2＋ and [Ru（bpy）2（ODCIP）Co]^4＋ were investigated by fluorescent spectra.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2008年第13期1565-1571,共7页
Acta Chimica Sinica
基金
国家自然科学基金(No.20601019)
广东省自然科学基金博士启动基金(No.04300882)资助项目
关键词
脱氧核糖核酸DNA
多吡啶钌配合物
双核
插入
荧光
DNA （deoxyribonucleic acid）
polypyridyl ruthenium（Ⅱ） complex
binuclear
intercalation
luminescence
