摘要
目的观察中药补肾方剂对大鼠实验性糖尿病牙周炎的治疗作用。方法选取纯种雄性SD大鼠随机分为3组,各30只:空白对照组(第1组)、糖尿病牙周炎组(第2组)及中药治疗组(第3组)。第2、3组大鼠按55mg/kg体重腹腔一次性注射链脲佐菌素并结扎上颌磨牙颈部建立糖尿病牙周炎动物模型,第3组用中药补肾方剂治疗,于用中药后1、2、3个月,每组各处死大鼠10只,取上颌骨标本进行骨计量学对比观察。结果第3组用中药后空腹血糖明显降低,附着水平丧失量及牙槽骨嵴高度丧失量均小于第2组,成骨细胞数大于第2组,并随用药时间延长效果更明显,差异有显著性(P<0.05)。结论补肾方剂能有效控制实验大鼠血糖;控制牙周组织炎症,促进牙槽骨形成。
Objective To observe the effect of tonifying kidney recipes （TKR） on diabetes periodontitis. Methods SD rats were randomly divided into three groups of thirty rats each. They included the control group （ 1 ^st group ）, the diabetes periodontitis group （2^nd group） and group TKR （3^rd group）. Streptozotocin was injected into the abdomen of the rats in the 2^rd and the 3^rd group to make the diabetes model, and the maxillary molars were ligated to make the periodontitis model. Rats of the 3^rd group were treated with TKR. The samples were collected for histological examination at 1^st, 2^nd, and 3^rd months after medicine administration, respectively. Results The blood sugar of the 3^rd group decreased significantly after medicine administration （ P 〈 0.05 ）. The loss of the connective tissue attachment and alveolar bone height were significantly lower in the 3^rd group than those in the 2^nd group. Osteoblast number was significantly increased in the 3^rd group compared with the 2^nd group （ P 〈 0.05 ）. Conclusion TKR may play a role in controlling diabetes periodontitis by controlling inflammation in periodontal tissue and promoting ossification of alveolar bone.
出处
《现代口腔医学杂志》
CAS
CSCD
北大核心
2008年第4期383-385,共3页
Journal of Modern Stomatology
基金
河北省科学技术研究与发展计划项目(04276101D-80)
关键词
糖尿病
牙周炎
大鼠
补肾方剂
Diabetes Periodontitis Rats Tonifying kidney recipes
