摘要
目的:建立丙二醇的质量控制和二甘醇检查的方法。方法:直用气相包谱-质谱联用仪(GC-MS)对丙二醇和二甘醇同时进行分析;色谱柱起始温度40℃,维持时间5 min,以20℃·min^(-1)速率升至80℃,维持1 min,再以30℃·min^(-1)升至250℃,维持5 min,不分流进样,通过监测总离子流色谱图以及色谱峰的质谱网,对丙二醇、杂质以及二甘醇进行检测。结果:该方法对丙二醇和二甘醇都具有良好的专属性、灵敏度和精密度。结论:该方法能用于丙二醇的质量控制和其中的二甘醇的检查。
Objective：To establish a method for quality control and diethylene glycol test of propylene glycol Method： Propylene glycol and diethylene glycol were simultaneously analyzed by GC - MS ; The column temperature was advanced gradually ： initial temperature was 40 ℃ for 5 minutes, then upgraded with a rate of 20 ℃·min^-1 to 80 ℃ remaining 1 minute,and the final temperature was promoted to 250 ℃ by a rate of 30 ℃ ·min^-1 and remained 5 minutes. After injected by a splitless mode, the identification and impurity test of propylene glycol were generated according to the TIC and El -MS spectrograms. Results：This method was satisfactory specificity, sensitivity and precision for propylene glycol and diethylene glycol analysis. Conclusion：It can be used for quality control of propylene glycol and diethylene glycol test.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2008年第6期942-944,共3页
Chinese Journal of Pharmaceutical Analysis
