摘要
目的:制备独一味自微乳化软胶囊(SMESC),并考察其溶出度。方法:通过溶解度实验,三元相图的绘制,体外乳化和稳定性实验确定最佳处方;以市售独一味胶囊为参比制剂测定SMESC的溶出度。结果:该SMESC中的乳化剂为Labrasol,助乳化剂为Transcutol P,油相为油酸乙酯,其比例为60∶25∶15。SMESC在水中10min的溶出度可达85%以上,而独一味胶囊60min的溶出度不足50%。结论:SMESC与市售胶囊剂相比,其在水中的溶出度显著提高。
Objective： To prepare the self-microemulsifying soft capsule （SMESC） of Duyiwei and investigate its dissolution property. Methods： Through solubility experiment, self-microemulsification in vitro, drawing phase diagram and investigating the stability of solution, the optimum formulation was determined for Duyiwei. The dissolution of SMESC was measured, taking the commercial capsule as reference. Results： In the optimum formulation, Labrasol, Transcutol P and ethyl oleate were screened as emulsifier, comulsifier and oil phase, respectively. The optimized proportion was 60： 25： 15. The dissolution of SMESC in water was more than 85% in 10 minutes, while that of the commercial capsule was less than 50% in 60 minutes. Conclusion： In comparison with the commercial capsule, the dissolution of SMESC is sufficiently improved in water.
出处
《中药材》
CAS
CSCD
北大核心
2008年第6期907-910,共4页
Journal of Chinese Medicinal Materials
关键词
独一味
自微乳化软胶囊
溶出度
Duyiwei
Self-microemulsifying soft capsule
Dissolution
