摘要
目的：对113例药物性肝病患者进行分析，以验证国际共识标准的，临床实用价值。方法：通过回顾性分析，对2006～2007年在我院诊断为药物性肝病的患者113例按照国际药物性肝损害分型标准进行，临床分型，采用Maria标准及DDW—J标准进行评分，分析发生药物性肝病的药物相关性。结果：药物性肝病占同期住院的肝病病例的13．7％（113／822），其中肝细胞损害型占15．0％（17／113），胆汁淤积型占81．4％（92／113），混合型占3．5％（4／113）。Maria标准及DDW—J标准得出药物与肝病相关性的结论不尽相同。引起药物性肝病的药物主要是降脂药和免疫抑制剂，抗凝剂居第3位。结论：DDW—J标准与临床诊断比较接近，规范了药物性肝病的诊断标准，但是也有一定的局限性。
OBJECTIVE： To analyze 113 patients with drug- induced liver disease （DILD） so as to clinically validate the international generally accepted diagnostic criteria. METHODS： 113 DILD cases were reviewed and categorized according to international generally- accepted diagnostic criteria and then graded separately by Maria clinical scale and DDW J scale to analyze the correlations. RESULTS： 113 out of 822 patients with liver diseases were DILD （13.7%）, among whom 17 were of hepatocellular type （15.0%）, 92 cholestasis type（81.5% ） and 4 mixed type （3.5%） . Application of Maria clinical scale and DDW J scale led to different number of DILD cases diagnosed. DILD were mostly induced by antihyperlipidemic drugs and immunosuppressants followed by anticoagulant drugs. CONCLUSION： DDW-J scale, which is more close to clinical diagnostic criteria, contributed to the standardization of the diagnostic criteria of DILD, yet it has its limitations as well.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第20期1577-1578,共2页
China Pharmacy
