摘要
目的以丙泊酚为对照，观察1．3MAC的七氟烷对罗库溴铵、维库溴铵及阿曲库铵临床药效的影响。方法选择60例择期腹部手术的病人随机分为6组，每组10人。七氟烷罗库溴铵组（SR组）、七氟烷维库溴铵组（SV组）及七氟烷阿曲库铵组（SA组）分别吸入1．3MAC的七氟烷及静注芬太尼维持麻醉，丙泊酚罗库溴铵组（CR组）、丙泊酚维库溴铵组（CV组）及丙泊酚阿曲库铵组（CA组）以丙泊酚6mg·kg^-1·h^-1～8mg·kg^-1·h^-1及芬太尼维持麻醉。监测起效时间、最大抑制程度、作用时间、维持速率、恢复时间、恢复指数。结果七氟烷组与相应的对照组在最大抑制程度、恢复指数方面的无统计学差异，起效时间、作用时间、维持速率、恢复时间有统计学差异。结论七氟烷能明显延长罗库溴铵、维库溴铵以及阿曲库铵的作用时间和恢复时间并减少其起效时间、维持剂量，但对最大抑制程度和恢复指数则无明显影响。
Objective To investigate the effects of 1.3 MAC of sevoflurane on neuromuscular blockade by rocuronium, vecuronium or atracurium,as compared with propofol. Methods Sixty patients （ASA Ⅰ - Ⅱ ） aged 18 -60 years undergoing laparotomy were randomly divided into six groups （n = 10）. In group SR, SV and SA, anesthesisa was maintained at the end - tidal concentration of 1.3 MAC of sevoflurane, with continuous neuromuscular blockade by rocuronium, vecuronium or atracurium respectively; In group CR, CV and CA, only 6 mg ·kg^-1·h^-1 to 8 mg ·kg^-1·h^-1 of propofol was given intravenously to maintain anesthesia, with neuromuscular blockade by rocuronium, vecuronium or atracurium respectively. Accelerometer was employed to detect neuromuscular function with train - of - four stimulation. All patients were given fentanyl intermittently to maintain a relatively stable hemodynamics. Resuits The effectual time, duration, maintenance dose and recovery time of rocuronium, vecuronium and atracurium showed significant difference among these groups （ P 〈 0.05 ）. But there was no significant different between two corresponding groups （ group SR and group CR, group SV and group CV, group SA and group CA ） in maximum inhibition degree and recovery index （ P 〉0.05 ）. Conclusion 1.3 MAC of sevoflurane augmented and prolonged the neuromuscular block produced by rocuronium, vecuronium and atracurium, but not effected their maximum inhibition degree and recovery index.
出处
《国际麻醉学与复苏杂志》
CAS
2008年第3期201-204,共4页
International Journal of Anesthesiology and Resuscitation
