摘要
目的探讨Pre-S1抗原与乙型肝炎病毒血清标志物的关系及其在乙肝血清标志物阳性孕妇中的检测意义。方法采用酶联免疫吸附法对874例携带不同血清标志物阳性孕妇进行乙肝5项检测,同时对其用酶联免疫吸附法检测Pre-S1抗原。结果在HB sAg(+)、HBeAg(+)、HB cAb(+);HB sAg(+)、HBeAb(+)、HB cAb(+);HB sAg(+)、HBeAg(+)和HB sAg(+)、HB cAb(+)等4种模式中,Pre-S1抗原检出率分别为64.0%、49.2%、86.7%和48.6%。在HBeAg阳性者与HBeAg阴性者中,Pre-S1抗原的检出率经比较具有非常显著性差异(2χ=16.18,P<0.005)。结论Pre-S1抗原与HBeAg具有较好的一致性,能反映乙肝病毒复制情况,尤其可反映HBeAg阴性患者体内是否有病毒复制,乙型肝炎病毒5项标志物和Pre-S1蛋白联合检测对更好地早期诊断孕妇乙型肝炎病毒感染、了解病毒的复制情况,观察疗效及预后判断均具有重要意义。
Objective To investigate relationship between Pre-S1 antigen and HBV serological markeis and clinical significance of Pre-S1 antigen detection for those pregnant women with positive HBV serological markers. Methods Pre-S1 antigen and 5 items of HB serological markers were simultaneously detected by using ELISA for 874 pregnant women with different positive HBV serological markers. Results The positive detectahle rates of Pre-S1 in the four patterns： positive HBsAg, positive HBeAg, positive HBcAb composition pattern; positive HBsAg, positive HBeAb, and positive HBcAb composition pattern; positive HBsAg and positive HBeAg composition pattern and positive HBsAg and positive HBcAb composition pattern were 64.0% , 49.2% , 86.7% and 48.6% respectively. In positive detectable rate of Pre-S1 ar^tigen, there was very significant difference between the pregnant women with positive HBeAg and those pregnant women with negative HBeAg（χ^2 = 16. 18, P 〈 0. 005）. Conclusion There is a better consistency between Pre-S1 and HBeAg. Pre-S1 can reflect replication status of HBV in the body of pregnant women especially those pregnant women with negative HBeAg. Combined detection of 5 items of HB serological markers and Pre - S1 antigen could diagnose HBV infection of the pregnant woman early, learn reproduction and observe therapeutic effect of the treatment and predict prognosis of the pregnant woman.
出处
《中国妇幼健康研究》
2008年第4期344-345,共2页
Chinese Journal of Woman and Child Health Research
