摘要
目的探讨大疱性表皮坏死松解型药疹的发病原因、临床表现及治疗经验。方法回顾31例住院治疗的该型药疹患者的发病原因、诊断及治疗经过。结果致病药物包括解热镇痛药、抗生素、抗痛风药、中药等。皮损面积超过体表面积50%为18例(58.1%),黏膜受损者27例(87.1%)。经综合治疗,均痊愈。结论大疱性表皮松解型药疹病因、临床表现复杂;糖皮质类固醇、大剂量免疫球蛋白、适当局部护理及对症支持治疗对治疗大疱性表皮坏死松解型药疹有重要作用。
Objective To explore the causes, clinical features and appropriate therapies of drug-induced bullosa epidermolysis. Methods A retrospective study was performed on 31 patients with drug- induced bullosa epidermolysis. Results The main causative drugs included antipyretics,antibiotics, anti - gout drug and medici- nal herb, and so on. More than 50% of the body surface was involved in 18 cases （58.1% ）. Erosive mucous mem- brane lesions were presented in 27 cases （ 87.1% ）. By combined therapies, all healed. Conclusions The causes and clinical features of drug - induced bullosa epidermolysis are extremely complicated. The comprehensive therapeutics including corticosteroid , high dose of gamma globulin , supportive treatment, timely management of complications and adequate nursing care of skin and membrane are of utmost importance for curing drug - induced bullosa epidermolysis.
出处
《南华大学学报（医学版）》
2008年第2期203-205,共3页
Journal of Nanhua University(Medical Edition)
