摘要
目的:研究聚苯胺/金(PANI/Au)复合纳米纤维修饰电极能否高灵敏、高选择检测大脑神经递质多巴胺(DA)。方法:基于PANI/Au修饰电极,电化学方法检测DA的响应电流,脉冲伏安法分析DA和抗坏血酸(AA)共存下的情况。结果:PANI/Au修饰电极可以获得DA的响应电流分别是单纯PANI修饰电极和裸电极的1.5和2.4倍,并且检测到DA和AA的峰电位相差达260 mV。结论:PANI/Au复合纳米纤维修饰电极可以提高DA的检测灵敏度和选择性。
Objective To study whether the polyaniline/Au （PANI/Au） composite nanofibers-modified electrode can be used to sensitively and selectively determine neuro-transmitter dopamine. Methods The electrochemical method was used to detect the response of current of DA based on PANI/Au composite nanofibers-modified electrode. The coexistent system of DA and AA was analyzed by differential pulse voltammetry. Results The PANI/Au composite nanofihers-modified electrode had obtained the electrocatalytic anodic current of DA 1.5-fold higher than the pure PANI-modifled electrode did and 2.4-fold higher than the bare electrode did. And the separation between the voltammetric peaks of AA and DA was large （260 mV）. Conclusion The PANI/Au composite nanofibers have been demonstrated to be able to promote the sensitivity and selectivity of the detection of DA.
出处
《东南大学学报（医学版）》
CAS
2008年第4期250-255,共6页
Journal of Southeast University(Medical Science Edition)
基金
国家自然科学基金资助项目(60571031
90406023)
国家"973"计划资助项目(2006CB933206
2006CB705606)
关键词
复合纳米纤维
多巴胺
聚苯胺
金纳米颗粒
抗坏血酸
电化学
composite nanofibers
dopamine
polyaniline
Au nanoparticles
ascorbic acid
electrochemistry
