摘要
目的探讨老年轻度认知功能障碍（MCI）与氧自由基代谢、乙酰胆碱酯酶（AchE）、血脂及炎性介质的关系。方法分别检测老年MCI组（45例）与健康老年组（45例）记忆力、血清超氧化物歧化酶（SOD）、丙二醛（MDA）、AchE、血脂及白介素（IL）-1α、IL-6含量,并进行比较和相关分析。结果与健康老年组比较,MCI组各项记忆分及记忆商明显降低（均P〈0.05）;血清SOD及高密度脂蛋白（HDL）水平显著降低（P〈0.05-0.01）,血清MDA、AchE、IL-1α水平及总胆固醇（TC）、低密度脂蛋白（LDL）及载脂蛋白B（ApoB）水平显著增高（P〈0.05-0.01）。MCI组血清AchE水平与SOD水平呈负相关（r=-0.82,P〈0.01）,与MDA水平呈正相关（r=0.69,P〈0.01）;ApoB水平与TC、LDL水平正相关（r=0.71,0.76,均P〈0.01）。结论记忆障碍是老年MCI患者的认知功能损害特点;血清AchE含量增高,可能是导致Ach不足使认知功能下降的原因之一;老年MCI与氧化损伤、炎症反应及脂质代谢紊乱可能有一定相关性。
Objective To study the correlation between senile mild cognitive impairment （MCI） and metabolize of oxygen-derived free radicals, acetylcholinesterase （AchE）, blood lipids and inflammatory mediator. Methods Memory,the levels of superoxide dismutase （SOD）, malondialdehyde （MDA）, AchE, blood lipids, IL- 1α and IL-6 of MIC group（45 cases） and elder healthy group（45 controls） were measured, funther compare and correlative analysis were made. Results Compared with elder healthy group, memory score in each item and memory quotient in MCI group were significantly lower （ all P 〈 0.05 ） , the levels of serum SOD and high-density lipoprotein / （HDL） were significantly lower （P 〈 0.05 - 0. 01 ）, but the levels of MDA, AchE, IL-1 α, total cholesterol （TC） , low-density lipoprotein （LDL） and apolipoprotein B （ ApoB ） were significantly higher （ P 〈 0.05 - 0.01 ）. In MCI group,the level of serum Ache was negative correlated with levels of serum SOD （ r = - 0. 82, P 〈 0. 01 ） , and positively correlated with levels of serum MDA （ r = 0. 69, P 〈 0.01 ）, ApoB was positively correlated with TC and LDL（r =0.71,0.76 ,all P 〈 0.01 ）. Conclusions Hypomnesis is the characteristic of cognitive impairment in senile MCI patient. Increasing contents of serum Ache leaded Ach deficiently may be one of the reasons of cognitive function reducing. It maybe have some correlations between senile MCI with the oxidation impairment, inflammatory reaction and disorder of lipid metabolize.
出处
《临床神经病学杂志》
CAS
北大核心
2008年第3期201-203,共3页
Journal of Clinical Neurology
基金
国家自然科学基金创新研究资助项目(30672571)
国家中医药管理局科技研究专项(04-05JP65)
关键词
轻度认知功能障碍
氧自由基
乙酰胆碱酯酶
血脂
白介素
mild cognitive impairment
oxygen-derived free radicals
acetylcholinesterase
blood lipids
interleukin
