摘要
目的:探讨化学发光法在肝纤维化血清学指标测定中的应用价值。方法:对确诊的慢性乙型肝炎患者76例采用化学发光法测定血清纤维化指标水平,并进行肝组织纤维化分期。结果:HA、PⅢP、Ⅳ.C与肝纤维化分期的相关系数分别为0.693(P<0.01)、0.753(P<0.01)、0.742(P<0.01),说明随着肝纤维化程度的加重,HA、PⅢP、Ⅳ.C血清水平逐渐升高;而LN与肝纤维化分期无相关性。结论:慢性乙型肝炎患者血清HA、PⅢP、Ⅳ.C水平对肝纤维化的早期诊断有一定意义,检测结果具有高灵敏性、高稳定性、无交叉污染、报告时间大大缩短等优点。
Objective: To assess the practical value of chemiluminometry in measuring serum fibrosis index for the diagnosis of hepatic fibrosis. Methods. 76 serum samples from patients with chronic hepatitis B were examined for measuring fibrosis indexes using chemiluminometry technique, and liver biopsy was pertormed. Results. The levels of HA, PⅢP and Ⅳ. C were increased and correlated positively with stage of fibrosis (r= 0. 693, P〈0. 01; r=0. 753, P〈 0.01 ; r=0. 742, P〈0. 01). Conclusion. Serum fibrosis indexes can help predict the tendency of hepatic fibrosis, and the method produces results with the advantages of high sensitivity, high stability, cross-confamination-proof, and promptness.
出处
《医学理论与实践》
2008年第7期768-769,共2页
The Journal of Medical Theory and Practice
关键词
化学发光
乙型肝炎
肝纤维化
血清学指标
Chemiluminometry, Hepatitis B, Hepatitis fibrosis, Serum index