摘要
目的:用顶空气相色谱法测定氨苄西林钠舒巴坦钠中乙醇、二氯甲烷有机溶剂残留量。方法:利用顶空自动进样装置,外标法,在大口径弹性石英毛细柱上进行各组分分离,克服了进样量不准确的缺点,各组分间的分离度均符合要求。柱温:90℃;进样口温度:150℃;检测器温度250℃。顶空瓶平衡温度80℃,平衡时间30分钟。结果:平均回收率:乙醇100.3%二氯甲烷100.3%。结论:该方法利用顶空气相色谱法克服了进样量不准确,各组分分离度达不到要求的缺点,重现性好,精度高。
Objective： Using the headspace Gas- chromatography method to measure the assay of residual solvent （ethanol, methylene chloride ） meanwhile in Ampicillin Sodium and Sulbactarn Sodium. Methods： autoinjection using external standard headspace method , which make the component can be separated at the wide polarity elastic capillany column, the result is good. It overcoms the weakness of injecting measure. It can be entirely separated by this method.The oven temperature was set at 90℃, with injector at 150℃ and FID temperamre at 250℃. The equilibrium temperarare of headspace was set at 80℃, with time at 30 minutes. Results： the average recovery was at 100.3 and 100.3%for ethanol and methylene chloride. Conclusion： using the method can obtain a good repeatability, headspace Gaschromatography of Ampicillin Scdium and Sulbactam Scdium overcome the weakness of injecting measure, is entirely separated by this method and obtain highly precision, make the quantify accurate.
出处
《黑龙江医药》
CAS
2008年第4期28-29,共2页
Heilongjiang Medicine journal
关键词
顶空气相色谱法
残留溶剂
弹性石英毛细柱
Headspace Gas-chrcrnatography Method
residual solvent
elastic capilany column
