摘要
目的:研究急性淋巴细胞白血病(ALL)患儿应用大剂量甲氨蝶呤(MTX)化疗期间,MTX血药浓度与不良反应的关系,从而设定合理的MTX解救方案。方法:133例ALL标危患儿连续静脉滴注MTX 24 h后,监测48 h时MTX血药浓度(c48 h),并观察毒副作用。结果和结论:MTXc48 h≤0.1μmol/L是一个比较安全的浓度范围,在充分水化、碱化的同时,在MTXc48 h为0.3μmol/L左右时停止解救,在临床上仍然是安全的。
Objective： To study the relationship between serum concentration of methotrexate（MTX） and adverse reactions during high-dose methotrexate（HD-MTX） treatment in children with acute lymphoblaslie leukemia（ALL）, in order to adjust the rescue dose of calcium folinatc. Methods： One hundred and thirty three children with ALL of standard risk received HD-MTX treatment. After continuous intravenous infusion of MTX for 24 h, the serum concentration of MTX at 48 h was determined, and the adverse reactions were recorded. Results and conclusion： MTX is safe for patients when serum concentration of MTX at 48 h is less than 0. 1 μmol/L. With sufficient hydration and alkalinization, it is safe to halt rescue when serum concentration of MTX at 48 h is about 0. 3μmol/L
出处
《药学服务与研究》
CAS
CSCD
2008年第3期177-180,共4页
Pharmaceutical Care and Research
关键词
白血病
淋巴细胞
急性
儿童
甲氨蝶呤
血药浓度
药物副反应报告系统
亚叶酸钙
leukemia, lymphocytic, acute
child
methotrexate
plasma concentration
adverse drug reaction reporting systems
calcium folinate
