摘要
CD4^＋CD25^＋调节性T细胞（Tr）是一个具有独立功能的T细胞亚群，是机体维持自身免疫耐受的重要组成部分，在免疫病理、移植物耐受、阻止自身免疫反应和维持机体免疫平衡方面都有一定作用，其T细胞亚群在多种免疫性疾病中发挥重要的调节作用，但国内外有关该群细胞在肾脏疾病中作用的报道较少。
CD4^＋CD25^＋ regulatory T cells （Tr） ,a subset of T cells with independent function are present in the normal immune system as an essential cellular component for maintaining autoimmune tolerance and immune homeostasis . They play an important role in immunopathogenesis, transplant tolerance, preventing autoimmune response and keeping immunologic balance. Researchs suggested that CD4^＋CD25^＋ regulatory T cells are of critical importance in many immunological diseases, but there are few reports concerning the role of these cells in kidney diseases.
出处
《国际免疫学杂志》
CAS
2008年第4期260-262,共3页
International Journal of Immunology
基金
国家自然科学基金资助项目（30271234）
江苏省卫生厅资助项目（H200520）
