摘要
用ｒＩＦＮα２ｂ和ｒＩＦＮγ作为抗原建立了检测血清中相应抗体的间接ＥＬＩＳＡ法。在１８８名健康体检者中检出的１例抗ｒＩＦＮα２ｂ阳性，２例ｒＩＦＮγ阳性，类风湿性关节炎患者、全身性红斑狼疮患者、全身性红斑狼疮患者、混合性结缔组织病患者以及肿瘤患者的这二种ＩＦＮ抗体水平（Ａ，ｘ±ｓ）明显高于对照者（Ｐ＜００５）。抗体检出率为２９％～６３％
Serum autoantibodies against recombinant interferon-α 2b and interferon-γ were examined by an indirect ELISA method. We examined 188 healthy persons and 171 cases with autoimmune disease or tumor. The results showed that the anti IFN α 2b and anti IFN γ autoantibodies in patients with rheumatoid arthritis, systemic lupus erythematosus, mixed connective tissue disease and tumor are significantly higher than normal controls. ( P< 0.05) Antibody incidences in these diseases are 2.9%～6.3%.
出处
《镇江医学院学报》
1997年第3期283-284,共2页
Journal of Zhenjiang Medical College
关键词
自身抗体
干扰素
自身免疫病
肿瘤
Autoantibody interferon
Autoimmune disease
Tumor
