摘要
真核基因的表达是一个复杂的过程,包括转录、pre-mRNA剪接、翻译等步骤。其中转录和pre-mRNA的剪接是基因表达中的两个重要环节,它们都要通过复杂的蛋白复合物来执行功能。目前研究发现这两个过程并不是绝对独立的,而是偶联在一起同时进行的。多种蛋白的偶联作用将二者联系在一起。RNA聚合酶Ⅱ、SKIP、SMN以及新近发现的人类P100蛋白不仅参与基因转录调节,同时它们在剪接加工中也具有相应的作用。
Eukaryotic gene expression is a complicated process which involves transcription, pre-messenger RNA splicing, and other pre-mRNA processing steps. Transcription and pre-mRNA splicing are the key nuclear processes in gene expression, and both of them require multi-component protein complex to serve their function. Transcription and splicing are not independent events. Co- transcriptional splicing emerges as a new concept. Several protein factors common to both processes have suggested that they are functionally coordinated. Recently, RNA polymerase Ⅱ , SKIP, SMN, p100 protein were found to be the members involved in the gene transcription and splicing as well. The investigation of these cross-talk proteins will lead to the understanding of the mechanism of transcription and splicing.
出处
《医学分子生物学杂志》
CAS
CSCD
2008年第3期254-257,共4页
Journal of Medical Molecular Biology
基金
国家自然科学基金(No.30670441)
国家高技术研究发展计划(863计划)(No.2007AA02Z115)
天津市科委应用基础研究重点项目(No.07JCZDJC07300)
高等学校博士学科点专项基金(No.20040062003)~~
