摘要
目的:对我院3年来药物引起的608例药物不良反应(ADR)进行回顾性分析,为临床合理用药提供警示。方法:对608例ADR报告进行归纳和分析。结果:55岁以上患者居多,占40.63%,引起的ADR以静脉给药为主,占68.59%;抗感染药物ADR的发生率最高,占49.18%,其次为中药制剂,占30.43%;ADR的临床表现以皮肤损害为主,占38.98%。结论:ADR的发生与诸多因素有关,临床表现多样化,需要加强ADR的监测,在临床用药时应合理使用抗感染药物,慎重使用中药注射制剂,联合用药应注意配伍禁忌,以减少或避免ADR的发生,保障患者用药合理、安全、有效。
Objective： Over the past three years 608 patients with drug-induced adverse drug reaction （ADR） in our hospital were retrospectively analyzed to provide warning for the clinical reasonable medication Methods： ADR reports of 608 patients were analyzed and summarized. Results： The majority of patients （40. 63% ） were over 55-years-old, and the ADR was mainly caused by intravenous administration （68~ 59% ）. The first cause of ADR was uses of ant （30.43%）. The main i-infecti clinical ve drugs （49.18%） , and the second was uses of the traditional Chinese medicine manifestation of ADR was the skin damage （38.98%）. Conclusion： The occur- rence of ADR is affected by many factors, and the clinical manifestations are diversified. Therefore, we need to strengthen the monitoring of ADR, and should rationally and carefully use the anti-infective drugs and the injection of traditional Chinese medicine. We should pay attention to drug combination and contraindications in order to reduce or avoid ADR, and to use reasonably safe and effective medications.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2008年第11期971-974,共4页
Chinese Journal of New Drugs
关键词
药物不良反应
回顾性分析
合理用药
adverse drug reaction
retrospective analysis
rational use of drug
