摘要
目的 研究摄入含糖软饮料和果糖与男性痛风发生风险之间的关系。
设计 历时12年的前瞻性队列研究。
地点 医务人员随诊研究。
参与者 46393例无痛风病史的男性，通过填写经验证有效的食物频度调查表，提供他们摄入软饮料和果糖的信息。
结局评估指标 符合美国风湿病学院痛风调查标准的痛风新发病例。
结果 在12年的随访中，共报告新发痛风确诊病例755例。含糖软饮料摄入增多和痛风危险性升高相关。与每月饮用不足一份含糖软饮料相比，每周饮用5～6份的人发生痛风的多变量相对危险度是1．29（95％可信区间1．00～1．68），每天一份的是1．45（1．02～2．08），每天两份或两份以上的是1．85（1．08～3．16；趋势P值=0．002）。无糖软饮料和痛风发生的危险性无关（趋势P值=0．99）。摄入果糖每增加五分之一，相应的痛风发生的多变量相对危险度为1．00、1．29、1．41、1．84和2．02（1．49～2．75；趋势P值〈0．001）。摄入果糖的其他主要来源，比如所有种类的果汁或富含果糖的水果（苹果和橘子），也和痛风发生的风险升高相关（趋势P值〈0．05）。
结论 前瞻性数据提示摄入含糖软饮料和果糖与男性痛风发生风险升高显著相关。另外，富含果糖的水果和果汁也可以增加其危险性。无糖软饮料和痛风发生的危险性无关。
Objective To examine the relation between intake of sugar sweetened soft drinks and fructose and the risk of incident gout in men.
Design Prospective cohort over 12 years.
Setting Health professionals follow-up study.
Participants 46 393 men with no history of gout at baseline who provided information on intake of soft drinks and fructose through validated food frequency questionnaires.
Main outcome measures Incident cases of gout meeting the American College of Rheumatology survey criteria for gout.
Results During the 12 years of follow-up 755 confirmed incident cases of gout were reported. Increasing intake of sugar sweetened soft drinks was associated with an increasing risk of gout. Compared with consumption of less than one serving of sugar sweetened soft drinks a month the multivariate relative risk of gout for 5 - 6 servings a week was 1.29 （95% confidence interval 1.00 to 1.68）, for one serving a day was 1.45 （1.02 to 2.08）, and for two or more servings a day was 1.85 （1.08 to 3.16; P for trend = 0. 002）. Diet soft drinks were not associated with risk of gout （P for trend =0.99）. The multivariate relative risk of gout according to increasing fifths of fructose intake were 1.00, 1.29, 1.41, 1, 84, and 2.02 （ 1.49 to 2. 75; P for trend 〈 0. 001 ）. Other major contributors to fructose intake such as total fruit juice or fructose rich fruits （ apples and oranges） were also associated with a higher risk of gout （ P values for trend 〈0.05）.
Conclusions Prospective data suggest that consumption of sugar sweetened soft drinks and fructose is strongly associated with an increased risk of gout in men. Furthermore, fructose rich fruits and fruit juices may also increase the risk. Diet soft drinks were not associated with the risk of gout.
出处
《英国医学杂志中文版》
2008年第3期143-146,共4页
The BMJ Chinese Edition
