摘要
用放射配体测定受体法研究了黄嘌呤 (X) /黄嘌呤氧化酶 (XO)体系产生的超氧阴离子自由基 (O·2 )对 [3H]DL 谷氨酸与大鼠大脑皮层突触膜谷氨酸受体结合的影响 ,结果表明O·2 明显增强谷氨酸与其受体的结合力 ,此作用能被 2 苯基 1 ,2 苯并异硒唑 3 ( 2H)酮 (EBSELEN) ( 1 μmol/L)
Promotive effect of superoxide and inhibitory effect of EBSELEN on [ 3H]DL glutamate binding to rat cortical synaptosomal membranes were studied by radiolabeled receptor assay. O · 2 results in a marked increase of specific glutamate binding. EBSELEN (1 μmol/L ) shows an inhibition effect on glutamate binding influenced by O · 2.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1997年第6期537-539,共3页
Progress In Biochemistry and Biophysics
