摘要
目的观察斜床站立训练和生脉饮治疗对脊髓损伤(SCI)后兔肠系膜上动脉α1肾上腺素受体(α1AR)的影响。方法46只日本大耳白兔分为假手术组(n=6)、SCI组(n=10,简称损伤组)、SCI+生脉饮组(n=10,简称生脉饮组)、SCI+训练组(n=10,简称训练组)和SCI+生脉饮+斜床站立训练组(n=10,简称联合治疗组)。建立T5脊髓横断动物模型,术后第4天开始斜床站立训练和/或服用生脉饮,共治疗28d。用RT-PCR方法检测术后31d各组动物肠系膜上动脉α1a、α1b、α1dAR mRNA表达变化。结果生脉饮组、训练组、联合治疗组α1aAR、α1bAR、α1dAR mRNA表达与损伤组比较有不同程度的增强。结论生脉饮和斜床站立训练改善SCI后直立性低血压可能与上调肠系膜上动脉α1aAR、α1bAR、α1dAR mRNA表达有关。
Objective To observe the effect of tilting table exercise and shengmaiyin on alpha 1 adrenogenic receptor （αlAR） in the superior mesenteric artery after spinal cord injury （SCI） in rabbits. Methods 46 rabbits were randomly divided into the sham group （n=6）, SCI group （n=10）, shenmaiyin group （n= 10）, exercise group （n： 10） and combined treatment （shenmaiyin plus exercise） group （n= 10）. The rabbit model of SCI was established by complete transection of spinal cord at the T5 spinal segment. Tilting table exercise and shengmaiyin were applied to different groups for 28 days from 4 days after operation. The expression of αlaAR,αlbAR, αldAR mRNA in the superior mesenteric artery was detected by RT PCR at α1d after SCI. Results The mRNA expressions of αlaAR, αlbAR, αldAR subtypes increased to different extent in rabbits of the shengmaiyin group, exercise group and combined treatment group compared with those of SCI group. Conclusion The role of tilting table exercise and shengmaiyin improving orthostatic hypotension after SCI in rabbits may be related to up-regulation of αlaAR, αlbAR, αldAR mRNA in the superior mesenteric artery.
出处
《中国康复理论与实践》
CSCD
2008年第6期528-530,共3页
Chinese Journal of Rehabilitation Theory and Practice
关键词
斜床站立训练
生脉饮
脊髓损伤
直立性低血压
Α1肾上腺素受体
tilting table exercise shengmaiyin spinal cord injury orthostatic hypotension
alpha 1 adrenogenic receptor
