摘要
目的:研制一种用于治疗小儿腹泻巴布剂的最佳基质配比。方法:采用均匀设计实验结合SPSS回归分析,对持粘力、剥离强度、赋形性、反复揭贴性以及背衬材料的渗出情况进行了考察,优化巴布剂的基质设计。结果:巴布剂基质的最佳处方为明胶∶羧甲基纤维素钠(CMC-Na)∶聚丙烯酸钠(PANA)∶高岭土∶AlCl3∶柠檬酸∶聚乙烯吡咯烷酮K-30(PVPK-30)∶PEG400∶丙二醇∶吐温-80=0.25∶0.1∶0.2∶1.5∶0.4∶0.6∶0.8∶2∶1∶0.5。结论:此巴布剂工艺合理、质量可控,是一种安全、有效的透皮给药制剂。
Objective：To optimize the matrix formulation of cataplasm used to cure infantile diarrhea.Methods：The optimum proportion of matrix for the preparation technology process of cataplasm was selected by uniform design and SPSS regression analysis.A check-up for adhibition,peeling strength,nonflowing,content of cream was founded.Results：The best matrix＇s prescription gelatin∶CMC-Na∶PANA∶kaolin∶aluminum trichloride∶citric acid∶PVP K-30∶PEG400∶trimethylene glycol∶tween-80 was 0.25∶0.1∶0.2∶1.5∶0.4∶0.6∶0.8∶2∶1∶0.5.Conclusion：The preparation technique of cataplasm is feasible,and its quality is steerable,it is a safe and effective transdermal-drug delivery system.
出处
《中药材》
CAS
CSCD
北大核心
2008年第5期748-750,共3页
Journal of Chinese Medicinal Materials
关键词
巴布剂
均匀设计
基质
Cataplasm
Uniform design
Matrix
