摘要
目的探讨内源性β-葡萄糖醛酸酶(β-glucuronidase,β-G)活性在原发性肝内胆管结石形成中的作用和意义。方法采用改良的Fishman方法对原发性肝内胆管结石患者胆汁、唾液中内源性β-G进行测定,分析内源性β-G活性变化与肝内胆管结石的关系。结果无论术前及术后,肝内胆管结石患者胆汁和唾液中内源性β-G活性均明显高于对照组(<0.05);与术前相比,术后2周胆汁和唾液中内源性β-G水平均较术前降低,但是只有胆汁内源性β-G水平变化有统计学意义(<0.05)。结论内源性β-G可能与原发性肝内胆管结石的成石有关。
Objective To investigate the role of endogenous β-glucuronidase in the formation of primary intrahepatic bile duct stone. Methods The activity endogenous of β-glucuronidase in the bile and saliva was tested by modified Fishman method, and comparison and metastasis of the relation between endogenous β-glucuronidase and bile duct stone patterns were performed. Results Expression levels of endogenous β-glucuronidase of bile and saliva in primary intrahepatic bile duct stone group were both higher than in the control group either pre-operation or post-operation （P〈0.05）. Bile endogenous β-glucuronidase, instead of saliva endogenous β-glucuronidase, was statistically higher pre-operation than post-operation. Conclusion Endogenous β-glucuronidase may play a role in the formation of primary intrahepatic bile duct stone.
出处
《医学新知》
CAS
2008年第3期156-157,共2页
New Medicine
关键词
内源性Β-葡萄糖醛酸酶
肝内胆管结石
endogenous β－glucuronidase
primary intrahepatic bile duct stone
