摘要
目的:研究丁螺环酮贴剂对小鼠的抗焦虑作用。方法:应用小鼠应激性直肠升温、爬梯及悬尾试验,观察丁螺环酮贴剂抗焦虑的药效和维持作用时间。结果:与对照组比较,丁螺环酮贴剂B、C(30、60mg/kg)组直肠温度均显著降低(P<0.05,P<0.01);丁螺环酮贴剂A(15mg/kg)、C组后肢站立数与对照组比较,差异具有显著性统计学意义(P<0.05,P<0.01),丁螺环酮贴剂B、C组后肢站立时间与对照组比较,差异具有显著性统计学意义(P<0.05,P<0.01),丁螺环酮贴剂B组总爬梯数与对照组比较,差异具有非常显著性统计学意义(P<0.01);丁螺环酮贴剂B、C组静相累积时间与对照组比较,差异具有非常显著性统计学意义(P<0.01),丁螺环酮贴剂C组身体扭动次数与对照组比较,差异具有显著性统计学意义(P<0.05);丁螺环酮贴剂(100mg/kg)维持作用时间可达120min。结论:丁螺环酮贴剂对小鼠具有明确的抗焦虑作用,最佳剂量为60mg/kg,维持作用时间为120min。
Objective：To study the effect of Buspirine patch on antianxiety in mice. Methods：The effect and maintained time of Buspirion patch on antianxiety with stress-induced by hyperthermia,staircase test and prolonging immobility phase in tail suspension of mice were observed. Results：Compared with the control group,the dose of Buspirine patch group B and C （30,60 mg/kg）showed significant decrease on stress-induced hyperthermia in mice（P 〈 0.05 ,P 〈 0, 01 ）, Buspirine patch group A（ 15 mg/kg）and C when compared with the control group showed significant statistical difference（ P 〈 0.05 ,P 〈 0.01 ） Buspirine patch group B and C were compared with the control group and showed significant statistical difference （P 〈 0.05, P 〈 0.01 ）. The total ladder climbing of group B, when cmpared with the control group, showed sigfificant statistical difference（P 〈 0.01 ）. The rearing time and frequency of Buspirine patch was shortened compared with the control group. Buspirine patch in group B and C significantly increased the immobility phase time in tail suspension with significant difference when compared with that of the control group （ P 〈 0.01 ）. The twisting times of Buspirine patch group C showed significant statistical difference（ P 〈 0.05 ） ,when compared with that of the control group. Buspirine patch 100 mg/kg maintained effect for 120 min. Conclusion： Buspirine patch has significant antianxiety effect. The best dosage is 60 mg/kg, and maintaining effect is 120 min.
出处
《华北国防医药》
2008年第3期59-61,共3页
Medical Journal of Beijing Military Region
关键词
丁螺环酮贴剂
抗焦虑
小鼠
应激性直肠升温
爬梯试验
悬尾
Buspirion patch
Ntianxiety
Mice
Stress-induced by hyperthermia
Staircase test
Tail suspension
