摘要
p53基因的表达产物p53蛋白可激活其下游基因Mdm2,使之发生转录,进而翻译成Mdm2蛋白;而Mdm2蛋白又会反过来对p53蛋白实施负调节,从而降低p53蛋白的水平.讨论p53和Mdm2蛋白系统的负反馈环模型.研究p53和Mdm2系统的调控特性以及典型的振荡行为.讨论p53和Mdm2系统的极限环振荡.计算了p53和Mdm2定态值随参数的变化关系,表明存在超临界霍普夫分岔.
P53 protein, expressed product of p53 gene, can activate its downstream gene Mdm2, induce Mdm2 gene to transcribe, and finally Mdm2 gene is translated into Mdm2 protein; conversely, Mdm2 protein negatively regulates p53 protein to decrease the level of p53 protein. In this paper, we discuss a negative feedback loop model to study the dynamical mechanism of p53 and Mdm2 protein system. The typical oscillatory behaviors for the activities of p53 and Mdm2 proteins are described. The limit-cycle oscillations of p53 and Mdm2 around the unstable stationary point are studied respectively. The steady values of p53 and Mdm2 as ftmctions of parameter are calculated which show supercritical Hopfbifurcations.
出处
《河北工业大学学报》
CAS
2008年第3期1-4,共4页
Journal of Hebei University of Technology
基金
国家自然科学基金(10375016)
河北省自然科学基金(A2007000001)
关键词
基因
极限环
振荡
负反馈
分岔
gene
limit-cycle
oscillation
negative feedback
bifurcation
